PD-1 regulates KLRG1+ group 2 innate lymphoid cells
نویسندگان
چکیده
منابع مشابه
PD-1 regulates KLRG1+ group 2 innate lymphoid cells
Group 2 innate lymphoid cells (ILC-2s) regulate immune responses to pathogens and maintain tissue homeostasis in response to cytokines. Positive regulation of ILC-2s through ICOS has been recently elucidated. We demonstrate here that PD-1 is an important negative regulator of KLRG1+ ILC-2 function in both mice and humans. Increase in KLRG1+ ILC-2 cell numbers was attributed to an intrinsic defe...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 2017
ISSN: 0022-1007,1540-9538
DOI: 10.1084/jem.20161653